Rational Clinical Examination Series

 But first!!!

Email from the CMO of UUH: Procalcitonin now available for ED testing to evaluate for Sepsis/SIRS.

Essential Evidence Plus

 

 

What sort of article are we reading – how should we prepare?

 

  • JAMA Site – Rational Clinical Examination Series

 

 

  • Systematic Review Validity

 

  • Diagnostic Test Validity

 

  • What can this study tell us? (what are the questions?)
    • prevalence of bacteremia
    • usefulness of blood cultures in detecting bacteremia

 

 

Levels of Evidence?

What evidence do we look for to answer the question?

 

Level 1 evidence

greater than 100 subjects, consecutive enrollment 

level 2 evidence

Prospective, fewer than 100 subjects, consecutive enrollment

level 3 evidence

Retrospective

level 4 evidence

any study of patients looking at possible bacteremia

 

 

Details

 

Likelihood Ratio Ranges/Interpretation

Derivation and Validation Sets